On The Crosstalk of Circadian Rhythm and Th17 cells: An Integrated Biological Regulatory Pathway

Hafeez Ur Rahman; Jamil Ahmad; Shagufta Naz; Muhammad Salam; Haseena Noureen

Authors

Hafeez Ur Rahman Department of Computer Science & Information Technology (University of Malakand, KP, Pakistan)
Jamil Ahmad Department of Computer Science & Information Technology (University of Malakand, KP, Pakistan)
Shagufta Naz Institute of Women’s Health (University College London, UK)
Muhammad Salam Department of Computer Science & Information Technology (University of Malakand, KP, Pakistan)
Haseena Noureen Department of Computer Science & Information Technology (University of Malakand, KP, Pakistan)

Keywords:

CD4+ Th17 cell, Cell-mediated immunity, Circadian rhythm, ROR, NFIL3

Abstract

Th17 cells play a pivotal role in cell-mediated immunity and also have implications for autoimmune disorders. The interplay between the circadian rhythm and the immune system has driven interest in developing novel therapies. Th17 cells have a robust relationship with the circadian rhythm through clock-controlled genes such as NFIL3 (E4BP4), RORA, RORB, NR3C1, and RORC. The purpose of this study is to construct a literature-curated updated biological regulatory network (BRN) of the molecular regulators of circadian rhythm and CD4+ Th17 cells. The integrated BRN will provide a holistic view of the differentiation process of Th17 cells from a circadian rhythm perspective, which will enhance our understanding of the interplay between the two systems. We aim to perform formal modelling and analysis of this BRN using our previously developed approaches to gain system-wide insights into various molecular expression dynamics and identify the significance of biological clocks in immunity in the future. In addition, biological pathway databases are an integral part of omics analytical workflows, and their continuous updates with the latest knowledge are crucial for gaining biological insights from such studies. Therefore, with this additional objective, we have also uploaded this pathway to WikiPathways (Database), to facilitate its use in future studies, which can be accessed via the following URL: https://classic.wikipathways.org/index.php/Pathway:WP5130. To our knowledge, this is the first study to report a literature-curated pathway of comprehensive regulatory interactions and crosstalk between Th17 cell differentiation and circadian genes.

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